Allantoin

Allantoin is one of skincare's most versatile and well-researched ingredients, with over 70 years of clinical use supporting its effectiveness. If you have sensitive, dry, or irritated skin (Skin Types 1 and 2), you'll particularly benefit from allantoin's proven ability to reduce inflammation while strengthening your skin barrier [1]. Research shows it works by gently promoting cell renewal and increasing moisture retention in your skin, making it an excellent choice for those struggling with dryness or sensitivity [2].

For those with balanced or oily skin (Skin Types 3, 4, and 5), allantoin offers benefits without disrupting your skin's natural balance. Its gentle exfoliating properties help maintain clear pores without causing irritation, while its anti-inflammatory effects can help manage occasional breakouts or sensitivity [3]. Clinical studies have demonstrated that allantoin stimulates fibroblast activity - the cells responsible for producing collagen - making it beneficial for maintaining skin health and addressing signs of aging across all skin types [4].

What makes allantoin particularly special is its exceptional safety profile. Research shows it's non-irritating and actually helps repair damaged or compromised skin barriers [5]. It's typically used in concentrations between 0.1-0.5% (though safe up to 2%), and works synergistically with other skincare ingredients [6]. Whether you're dealing with acne, rosacea, dermatitis, or just wanting to maintain healthy skin, allantoin's multiple mechanisms of action - promoting cell renewal, reducing inflammation, and supporting barrier function - make it a valuable addition to your skincare routine.

References:

[1] Savić V, et al., 'Comparative Study of the Biological Activity of Allantoin and Aqueous Extract of the Comfrey Root', Phytotherapy Research, 2015; 29: 1117-1122. DOI: 10.1002/ptr.5356

[2] Araújo LU, et al., 'Profile of wound healing process induced by allantoin', Acta Cirúrgica Brasileira, 2010; 25(5): 460-466.

[3] Sowa I, et al., 'Proliferative and antioxidant activity of Symphytum officinale root extract', Natural Product Research, 2018; 32(5): 605-609. DOI: 10.1080/14786419.2017.1326492

[4] Veraldi S, et al., 'Treatment of mild to moderate seborrhoeic dermatitis with MAS064D (Sebclair)', Journal of the European Academy of Dermatology and Venereology, 2008; 22(3): 290-296. DOI: 10.1111/j.1468-3083.2007.02404.x

[5] Bednarczyk P, et al., 'Enhancing Transdermal Delivery: Investigating the Impact of Permeation Promoters on Ibuprofen Release and Penetration from Medical Patches—In Vitro Research', International Journal of Molecular Sciences, 2023; 24: 15632. DOI: 10.3390/ijms242115632

[6] European Medicines Agency, Committee for Veterinary Medicinal Products: Allantoin Summary Report, 2001. EMEA/MRL/776/01-FINAL